TY - JOUR AU - Abdel-Wahhab, Khaled Gamal El-Deen AU - El-Shamy, Karima Abbas AU - El-Beih, Nadia Abd El-Zizz AU - Morcy, Fatma Adly AU - Mannaa, Fathia Abd Elwahid PY - 2011/04/19 Y2 - 2024/03/29 TI - Protective effect of a natural herb (Rosmarinus officinalis) against hepatotoxicity in male albino rats JF - Comunicata Scientiae JA - Com. Sci. VL - 2 IS - 1 SE - Original Article DO - 10.14295/cs.v2i1.82 UR - https://comunicatascientiae.com.br/comunicata/article/view/82 SP - 9-17 AB - <span lang="PT-BR"><p align="justify">The present study was conducted to study the chemoprotective effect of Egyptian rosemary extract (RE) against CCl<sub>4</sub>-induced hepatotoxicity. Eight experimental groups were used as follow: (1) control; (2&3) RE alone (440 mg/kgb.w) for 4 and 8 weeks, respectively; (4) CCl<sub>4</sub> (1ml/kg b.w, twice a week, i.p) for 4 weeks; (5&7) RE (220&440 mg/kg) for 4 weeks before CCl<sub>4</sub> for a similar period; and (6&8) RE (220&440 mg/kg) for four weeks before CCl<sub>4</sub> in combination with RE another four weeks. The sequential CCl<sub>4</sub> treatment induced significant changes in serum biochemical parameters accompanied by sever histological and histochemical changes of the liver tissue, while administration of 440 mg/kg/day for either 4 or 8 weeks did not induce any changes. Administration of RE before or during the treatment with CCl<sub>4</sub> improved all biochemical parameters and histological picture of the liver, in a dose and duration-dependant manner. It could be concluded that RE has a protective effects against hepatotoxicity.</p></span> ER -