TY - JOUR AU - Fahmy, Maha Aly AU - Aly, Fawzia Abd Elfatah AU - Hassan, Emad Mohamed AU - Farghaly, Ayman Ali AU - Hassan, Entesar Elsayed AU - Samea, Negm Sayed Abdel PY - 2020/04/07 Y2 - 2024/03/28 TI - Cymbopogon citratus essential oil has hepato/renal protection and anti-genotoxicity against carbon tetrachloride JF - Comunicata Scientiae JA - Com. Sci. VL - 11 IS - SE - Original Article DO - 10.14295/cs.v11i0.3219 UR - https://comunicatascientiae.com.br/comunicata/article/view/3219 SP - e3219 AB - <p>Nowadays, there is an increasing trend to use aromatherapy for treatment of various diseases. <em>Cymbopogon citratus</em> (Lemongrass) is one of many plants which have been reported to employ&nbsp;successfully in aromatherapy. Herein we decided to explore the protective role of <em>Cymbopogon citratus</em> essential oil (CCEO) against hepato/renal damage and genotoxicity induced by carbon tetrachloride (CCl<sub>4</sub>) and the relation of this bioactivity with its chemical constituents. Six main groups of mice (five/each) were examined: I- represents negative control group, II and III- mice received oral treatment with CCl<sub>4 </sub>(1mL/kg, positive control) and CCEO (0.3 mL/kg, control plant) respectively for five consecutive days and IV-VI- represent groups of mice treated with CCEO at the three concentrations 0.1, 0.2, 0.3 mL/kg plus CCl<sub>4 </sub><br> (five consecutive&nbsp;days treatment). Remarkable adverse effects of CCl<sub>4 </sub>in all the tested parameters were recorded. These effects were distinguished as an increment in the level of all liver marker enzymes (ALT, AST, ALP, <strong>γ</strong>-GT), blood urea, and creatinine. Also the oxidative stress biomarkers: malondialdehyde (MDA) and glutathione-transferase GST were affected after CCl<sub>4 </sub>treatment. Regarding to the genotoxic effect of CCl<sub>4</sub>, the percentage of chromosomal aberrations in bone marrow and spermatocyte cells was elevated (p&lt; 0.05) compared with the negative control. Notable antioxidant, hepato/renal protection and anti-mutagenic potency of CCEO against CCl<sub>4 </sub>were demonstrated with a dose-related relationship. GC/MS analysis demonstrated the presence of 12 phytochemical constituents which in combination play a critical role in its antioxidant/antigenotoxic efficacy. The major components exist were E. Citral (35.13%) and Geraniol (32.83%).</p> ER -